Macroglossia: A Large Retrospective Analysis That Is Not Just Tongue-in-Cheek

We normally associate macroglossia with Beckwith-Wiedemann Syndrome (BWS) but what if it’s not? Prada et al. (doi: 10.1542/peds.2011-1732) share the results of their series of 135 children with macroglossia at Cinncinnati Children’s Hospital Medical Center from 1997 to 2010. More than 13 different diagnoses are represented in this case series, and less than half of those studied (who were referred largely for their large tongues), had BWS. If you want to broaden your differential so that more than BWS rolls off your tongue when you see a patient with macroglossia, don’t miss this interesting article.